Combined protein C and protein S deficiency with pregnancy

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Avascular necrosis of hip following combined protein C and protein S deficiency.

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Protein C and protein S deficiency - practical diagnostic issues.

Protein C (PC) and protein S (PS) are vitamin K-dependent glycoproteins, that act as natural anticoagulants. The proteolytic activation of PC by thrombin occurs on the surface of endothelial cells and involves thrombomodulin and endothelial PC receptor. In the presence of PS, phospholipids and calcium, activated PC (APC) inactivates membrane bound factors V (FVa) and FVIIIa by their cleavage at...

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Lacunar infarction in child with Protein S deficiency: a case report

Abstract Arterial ischemic stroke defines as a new focal neurologic deficit that lasted 24 hours or longer. Stroke is relatively rare in children and incidence of cerebrovascular disease is 1 per 4000 in neonates and 1 per 7000 to 1 per 70000 in older children (1 month to 18 years). Protein S deficiency is one of the causes of the stroke in children. Major manifestations of protein S deficienc...

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Protein Deficiency and Pregnancy Anaemias'

Protein deficiency was reported to cause normocytic normochromic anaemia in rhesus monkeys (Sood et al., 1965). Adams et al., (1967) were impressed by the similarity between the anaemia in protein deficient rhesus monkeys and anaemia in kwashiorkor. Ghitis et al., {1963) and Allen & Dean {1965) were also of the opinion that protein deficiency was an important cause of anaemia in kwashiorkor. Th...

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[Protein C deficiency].

Severe protein C deficiency (i.e. protein C activity <1 IU dL(-1)) is a rare autosomal recessive disorder that usually presents in the neonatal period with purpura fulminans (PF) and severe disseminated intravascular coagulation (DIC), often with concomitant venous thromboembolism (VTE). Recurrent thrombotic episodes (PF, DIC, or VTE) are common. Homozygotes and compound heterozygotes often pos...

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ژورنال

عنوان ژورنال: International Journal of Reproduction, Contraception, Obstetrics and Gynecology

سال: 2016

ISSN: 2320-1770

DOI: 10.18203/2320-1770.ijrcog20162148